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New insights into Ruthenium arene anticancer agents

on Wed, 25/11/2015 - 08:26

Table of Contents graphical abstractOur most recent publication is now available in Inorg. Chem. ASAP. Congrats to Thamy and Shirin on their hard work putting this manuscript together. "The impact of Lewis acids on the Ru—S bond in Ruthenium(II) Arene Anticancer Complexes is evaluated using a combination of X-ray absorption spectroscopy and density functional theory calculations. We conclude that Ru—S bond lability is dramatically affected by electrophilic activation of the terminal oxo in sulfenato complexes, which should play an important role in defining the chemical behavior of these species in vivo."